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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $54 | In Stock | |
10 mg | $87 | In Stock | |
25 mg | $185 | In Stock | |
50 mg | $369 | In Stock | |
100 mg | $555 | In Stock | |
1 mL x 10 mM (in DMSO) | $54 | In Stock |
Description | VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes. |
In vitro | VU0357121 do not bind at the MPEP allosteric site of mGlu5, thus do not possess mGlu5 NAM activity. The A809V/rmGlu5 mutation inhibited the ability of VU0357121 to shift the glutamate concentration?response curve, whereas the response to VU0357121 is not altered by the F585I/rmGlu5 mutation. [1] VU0357121 show weaker cooperativity in the Ca2+ mobilization assay in the low-expressing HEK293A-mGlu5 cell line. [2] |
Molecular Weight | 305.32 |
Formula | C17H17F2NO2 |
Cas No. | 433967-28-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 30.5 mg/mL (100 mM) DMSO: 30.5 mg/mL (100 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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